In people with normal absorption, deficiencies have been reported only in strict vegetarians who consume no products of animal origin (including no milk products or eggs). Vitamin B 12 is not present in foods of plant origin, but is abundant in foods of animal origin. The average diet supplies about 5 to 15 mcg/day of vitamin B 12 in a protein-bound form that is available for absorption after normal digestion. Prompt parenteral administration of vitamin B 12 prevents progression of neurologic damage. Intrinsic factor deficiency causes pernicious anemia, which may be associated with subacute combined degeneration of the spinal cord. Gastrointestinal absorption of vitamin B 12 depends on the presence of sufficient intrinsic factor and calcium ions. Intravenous administration results in even more rapid excretion with little opportunity for liver storage. The major portion is excreted within the first eight hours. Within 48 hours after injection of 100 or 1,000 mcg of vitamin B 12, 50 to 98% of the injected dose may appear in the urine. The liver is the main organ for vitamin B 12 storage. Absorbed vitamin B 12 is transported via specific B 12 binding proteins, transcobalamin I and II to the various tissues. Vitamin B 12 is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis.Ĭyanocobalamin is quantitatively and rapidly absorbed from intramuscular and subcutaneous sites of injection the plasma level of the compound reaches its peak within 1 hour after intramuscular injection. You may report side effects to FDA at 1-80.Related/similar drugs Vitamin B12, Dodex, hydroxocobalamin, Nascobal Cyanocobalamin - Clinical Pharmacology Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. Low potassium level-leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.Ĭommon side effects of cyanocobalamin may include: Heart problems-swelling, rapid weight gain, feeling short of breath įluid build-up in or around the lungs- pain when you breathe, feeling short of breath while lying down, wheezing, gasping for breath, cough with foamy mucus, cold and clammy skin, anxiety, rapid heartbeats or Get emergency medical help if you have signs of an allergic reaction: hives difficulty breathing swelling of your face, lips, tongue, or throat.Ĭyanocobalamin may cause serious side effects. Keep it out of the reach of children and pets. Follow state or local laws about how to dispose of this container. Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Store this medication at room temperature away from moisture, heat, and light. Tell any doctor who treats you that you are using cyanocobalamin. Use all medications as directed.Ĭyanocobalamin can affect the results of certain medical tests. Folic acid alone will not treat Vitamin B12 deficiency or prevent possible damage to the spinal cord. Pernicious anemia is also treated with folic acid to help maintain red blood cells. Untreated vitamin B12 deficiency can lead to anemia or irreversible nerve damage. Do not stop using the medicine unless your doctor tells you to. Your child's dose will depend on age, weight, diet, and other factors.įor pernicious anemia, you may have to use cyanocobalamin for the rest of your life. Tell your doctor about any changes in your diet or medical condition.Īlways follow directions on the medicine label about giving cyanocobalamin to a child. Your dose needs may change if you become pregnant, if you breastfeed, or if you eat a vegetarian diet. A healthcare provider may teach you how to properly use the medication by yourself. Use the medicine exactly as directed.Ĭyanocobalamin injection is injected into a muscle or under the skin. Related/similar drugs cyanocobalamin, Vitamin B12, Dodex, hydroxocobalamin, Nascobal How is cyanocobalamin injection given?įollow all directions on your prescription label and read all medication guides or instruction sheets.
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